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Image Search Results
Journal: Neuron
Article Title: Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia
doi: 10.1016/j.neuron.2014.07.028
Figure Lengend Snippet: (A) Representative traces of excitatory post-synaptic potentials (EPSP) evoked by superficial layer electrical stimulation in adult PFC before (black trace) and after (green trace) bath application of the D2-agonist quinpirole (5 μM). (B) Neurobiotin-filled layer V pyramidal cell in the PFC; the relative position of the bipolar stimulating electrode and the recording electrode are shown schematically. (C) Bar graphs illustrating the magnitude of EPSP attenuation by quinpirole in slices from SHAM, NVHL, and NAC-treated NVHL rats. In sham rats, quinpirole reduces the size of the synaptic response, whereas in NVHL rats this attenuation is absent. NAC treatment during development reverses this deficit in NVHL animals (ANOVA: F(2,39)=3.328, p=0.046). (D) Traces from in vivo intracellular recordings in PFC pyramidal neurons showing responses to electrical stimulation of the ventral tegmental area (VTA) with trains of 5 pulses at 20 Hz in anesthetized SHAM (top), NVHL (middle), and NAC-treated NVHL (bottom) rats. Each panel is an overlay of 5 traces that illustrate the representative type of response observed in each group, with NVHL showing enhanced firing following VTA stimulation, while firing is sparse in SHAM and NAC-treated NVHL rats. (E) Bar graph illustrating group data for action potential firing in the 500 ms epoch following VTA stimulation in all three groups. ANOVA: F(2,37)=4.5, p<0.05; NVHL firing was higher than in shams (post-hoc Tukey's q=3.9, p<0.05) and higher than in NAC-treated NVHL rats (post-hoc Tukey's q=3.6, p<0.05). In all electrophysiology experiments data from SHAM and NAC-treated SHAM rats were combined as they did not show differences.
Article Snippet:
Techniques: In Vivo